Characterizing excitation-contraction coupling and function in isolated myocytes can be challenging and time-consuming. While studies utilizing our standard Calcium and Contractility system have proved extremely valuable in the past, higher throughput is required to accommodate faster drug discovery and a growing motivation in basic research toward large scale, rapid data collection and analysis. Isolated myocytes display a high degree of functional variability, which can result in poor characterization of key parameters calculating myocyte dynamics. Acquiring data from a much greater number of myocytes provides the statistical power to characterize myocyte function with greater accuracy and confidence. In the pharmaceutical setting, this is a significant enhancement in phenotype quantification as it expedites assessment of drug efficacy/toxicity and greatly reduces costs by eliminating dangerous or marginal compounds.
keyword : imaging, calcium imaging, ionoptix