company

TRIAL-UNIQUE NONMATCHING-TO-LOCATION TASK - TUNL - FOR MICE

  • TRIAL-UNIQUE NONMATCHING-TO-LOCATION TASK - TUNL - FOR MICE
  • TUNL can be thought of as a version of delayed nonmatching-to-place (DNMTP), in which the subjects are presented with a sample location and, following a delay, with the (incorrect, S-) sample location and a (correct, S+) nonmatching location. DNMTP has been shown to be vulnerable to non-spatial mediating strategies. TUNL eliminates these problems by using multiple, trial-unique locations, preventing the use of mediating strategies.

    Animals with lesions in the dorsal hippocampus or decreased hippocampal neurogenesis were impaired when the locations were close together, but not when they were far apart. This feature also renders the task exquisitely sensitive to hippocampal dysfunction, tapping both the role of the hippocampus in memory and in pattern separation.


    keyword : behavior, pharmacology, reward addiction, campden instruments ltd

  • READ MORE
  • QUOTE

search